January 7, 2019
1 minute, 12 seconds read
Cancer Care / Oncology, Bone Marrow Transplant, Hematology Oncology, Medical Oncology
Cancer can be a devastating diagnosis for anyone, especially when it strikes young children. B cell lymphoblastic Leukemia (ALL), is a type of blood cancer, which is very common in the younger age group. Treatment of ALL has come a long way. From single-agent methotrexate chemotherapy in the 1940s to multi-agent chemotherapy regimens, treatment for this disease has undergone a sea change. Survivals have also increased significantly. Now in 2018, we talk about cure rates of 70-80% as compared to few months survival about 4-5 decades back. Find the best cancer specialist in Delhi.
Challenge now is about 20-30% patients who have relapse refractory disease. CAR T cell therapy is a type of treatment in which a patient's T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. In the first step, T cells are taken from patient’s blood. Then the gene for a special receptor that binds to a certain protein on the patient’s cancer cells is added in the laboratory. The special receptor is called a chimeric antigen receptor (CAR). Large numbers of the CAR T cells are grown in the laboratory and given to the patient by infusion.
CAR T cells are very effective in treating relapsed and refractory B ALL patients. Efforts are going on to develop these cells in India to bring down the cost. Presently this therapy has FDA approval for ALL and lymphomas.