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Rheumatoid arthritis is a disorder of the joints and causes them to swell, pain, and stiffen. There are numerous types of rheumatoid arthritis (all are autoimmune disorders), including seronegative RA and seropositive RA.
The majority of people are diagnosed with seropositive rheumatoid arthritis. The type can be diagnosed with the help of lab testing for the substance called anti-cyclic citrullinated peptide (anti-CCP) antibodies or rheumatoid factor in the blood. People without these antibodies are diagnosed as seronegative. These patients may have other antibodies or none at all.
However, antibodies can develop at a later stage in life. If this occurs, doctors change their diagnosis to seropositive RA.
Some common signs and symptoms of seronegative rheumatoid arthritis are:
Seronegative rheumatoid arthritis is of four types:
Related: Arthritis Treatment in Delhi, India
The exact cause of seronegative rheumatoid arthritis is unknown. However, some factors that may be responsible for it are:
Doctors diagnose rheumatoid arthritis by assessing the symptoms and recording medical history, followed by lab and imaging tests. Patients with seronegative arthritis commonly present with specific symptoms and test negative for RF and anti-CCP antibodies. Some lab tests that help diagnose seronegative rheumatoid arthritis are:
Treatment of seronegative rheumatoid arthritis aims to alleviate pain and discomfort associated with inflammation of the joints. Treatment can slow or cease the progression of the disease.
Seronegative RA causes severe damage to the joints and bones. This is because the body cells attack the synovial tissues that cushion the bones. When this tissue and supporting cartilage deteriorate, the bones rub against each other. This worsens the condition of the bones with time.
Some forms of seronegative rheumatoid arthritis can be treated with NSAIDs. These drugs reduce inflammation and ameliorate the pain associated with joint swelling. In addition, these medications can increase the range of motion by reducing the swelling that leads to joint stiffness. Swelling also affects the range of motion of the joint.
Other medicines, like disease-modifying antirheumatic drugs (DMARDs), may slow the progression of joint damage caused by seronegative RA.
Injections of hyaluronic acid, corticosteroids, BOTOX®, and platelet-rich plasma (PRP) given intra-articularly can effectively reduce inflammation, relieve pain and improve the function of the affected joints.
Numerous herbal therapies relieve the symptoms of seronegative rheumatoid arthritis. They also help patients manage this disorder. Some supplements include fish oil, evening primrose, rosehips, frankincense, turmeric, probiotics, or glucosamine. This helps ease the affected joints and enhance the range of motion. However, before starting these, consulting with a rheumatologist is essential.
Physical therapy can help patients regain mobility by teaching new methods of moving their bodies to complete daily activities.
As the seronegative RA progresses, there is an increased risk of damage to the cartilage and joints. In such cases, reconstructive or joint replacement surgeries may be necessary to restore physical function and reduce pain.
Some complications associated with seronegative rheumatoid arthritis include:
Numerous factors contributing to the development of seronegative rheumatoid arthritis include:
The outlook for seronegative rheumatoid arthritis is better than that of seropositive rheumatoid arthritis. This may be suggestive of seronegative rheumatoid arthritis being a milder form of rheumatoid arthritis. However, for some people, the progression of the disease can be similar, and sometimes with time, the diagnosis can change to seropositive.
Max Healthcare is home to 5000 eminent doctors in the world, most of whom are pioneers in their respective fields. Additionally, they are renowned for developing innovative and revolutionary clinical procedures.
Max Healthcare is home to 5000 eminent doctors in the world, most of whom are pioneers in their respective fields. Additionally, they are renowned for developing innovative and revolutionary clinical procedures.
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